|
Weight Gain
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Different transcriptional control of metabolism and extracellular matrix in visceral and subcutaneous fat of obese and rimonabant treated mice.
|
19030233 |
2008 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Taken together, our data suggested a potential role of Myo1b in cervical carcinogenesis and tumor progression and provided novel insights into the mechanism of how this factor promotes cell proliferation, migration, and invasion in CC cells.
|
29395313 |
2018 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Taken together, our data suggested a potential role of Myo1b in cervical carcinogenesis and tumor progression and provided novel insights into the mechanism of how this factor promotes cell proliferation, migration, and invasion in CC cells.
|
29395313 |
2018 |
|
Tuberous Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our study demonstrates that Myo1b mediates the effect of Arg-II in activating mTORC1-S6K1 through promoting peripheral lysosomal positioning, that results in spatial separation and thus dissociation of TSC from lysosome, leading to hyperactive mTORC1-S6K1 signaling linking to cellular senescence/apoptosis.
|
29472548 |
2018 |
|
Toxoplasmosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Based on all the above findings, the current study proposes that pVAX1-MYR1 can induce a <i>T. gondii</i>-specific immune response and should therefore be considered as a promising vaccine candidate against toxoplasmosis.
|
31024505 |
2019 |
|
Squamous cell carcinoma of the head and neck
|
0.040 |
Biomarker
|
disease |
BEFREE |
Passenger strand of miR-145-3p acts as a tumor-suppressor by targeting MYO1B in head and neck squamous cell carcinoma.
|
29115582 |
2018 |
|
Squamous cell carcinoma of the head and neck
|
0.040 |
Biomarker
|
disease |
BEFREE |
Myo1b is functionally involved in lymph node metastasis of human HNSCC through enhanced cancer cell motility and is an attractive target for new diagnostic and therapeutic strategies for patients with HNSCC.
|
25421751 |
2015 |
|
Squamous cell carcinoma of the head and neck
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Increased miR-363 expression or siRNA knockdown of MYO1B expression reduced Transwell migration of SCCHN cell lines, indicating that the miR-363-induced migration attenuation of SCCHN cells may act through MYO1B downregulation.
|
26545583 |
2015 |
|
Squamous cell carcinoma of the head and neck
|
0.040 |
Biomarker
|
disease |
BEFREE |
Recent evidence suggests an important role of Myosin 1b (Myo1b) in the progression of several cancers, including prostate cancer and head and neck squamous cell carcinoma (HNSCC).
|
29395313 |
2018 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
DHRS2 and MYO1B were directly regulated by miR‑145‑3p in ESCC cells by dual luciferase reporter assays.
|
30535463 |
2019 |
|
Serum gamma-glutamyl transferase measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
22001757 |
2011 |
|
Serum gamma-glutamyl transferase measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
22001757 |
2011 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, Myo1b knockdown in SAS cells significantly inhibited in vivo cervical lymph node metastases in a cervical lymph node metastatic mouse model system.
|
25421751 |
2015 |
|
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
Rigor - Temperature-associated observation
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Here, we reveal the structural basis for force-sensing based on near-atomic resolution structures of one rigor and two ADP-bound states of myosin-IB (myo1b) bound to actin, determined by cryo-electron microscopy.
|
29358376 |
2018 |
|
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recent evidence suggests an important role of Myosin 1b (Myo1b) in the progression of several cancers, including prostate cancer and head and neck squamous cell carcinoma (HNSCC).
|
29395313 |
2018 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Myo1b is functionally involved in lymph node metastasis of human HNSCC through enhanced cancer cell motility and is an attractive target for new diagnostic and therapeutic strategies for patients with HNSCC.
|
25421751 |
2015 |
|
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
In contrast, fibroblasts activated by late-stage cancer-exosomes (SW620-Exos) display a striking ability to invade through extracellular matrix through upregulation of pro-invasive regulators of membrane protrusion (PDLIM1, MYO1B) and matrix-remodeling proteins (MMP11, EMMPRIN, ADAM10).
|
30582284 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Interestingly, high expression of MYO1B was associated with poor prognosis in patients with HNSCC by analysis of The Cancer Genome Atlas database (p=0.00452).
|
29115582 |
2018 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Also, silencing the expression of Myo1b dramatically repressed tumor growth in a mouse xenograft model.
|
29395313 |
2018 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Afterward, we investigated the expression levels of MYO1B and h-caldesmon (h-CD) in perivascular myoid cell neoplasms, angioleiomyomas (n=28), glomus tumors (n=23), and myopericytomas (n=3).
|
28088345 |
2017 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
HNSCC with high expression of Myo1b and chemokine receptor 4 (CCR4), another metastasis-associated molecule, was strongly associated with lymph node metastasis.
|
25421751 |
2015 |
|
Myopericytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Afterward, we investigated the expression levels of MYO1B and h-caldesmon (h-CD) in perivascular myoid cell neoplasms, angioleiomyomas (n=28), glomus tumors (n=23), and myopericytomas (n=3).
|
28088345 |
2017 |
|
Muscle Rigidity
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Here, we reveal the structural basis for force-sensing based on near-atomic resolution structures of one rigor and two ADP-bound states of myosin-IB (myo1b) bound to actin, determined by cryo-electron microscopy.
|
29358376 |
2018 |
|
melanoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|